In 1975, Behar published his study ‘Effect of calcium on magnesium absorption’ in the American Journal of Physiology. His study demonstrated that an increase in calcium levels within the body led to a decrease in magnesium. The decrease in Magnesium also saw a decrease in sodium.
This calcium effect was also observed when sodium chloride was replaced by urea. However, a consistent correlation was observed between the amount of net magnesium absorption and the rates of net water absorption of all calcium concentrations.
Behar’s findings suggest calcium decreases magnesium absorption by a nonspecific reduction in membrane permeability to solutes (the minor component in a solution) that induce net water flow and are consistent with the concept that magnesium is transported by solvent "drag".
The increase in the concentration of calcium resulted in an increase in tissue accumulation of magnesium. This increase in tissue accumulation of magnesium was associated with a decrease in net sodium absorption.
These findings suggest an additional mechanism of magnesium transport operating independently of net water flow.
Published in ‘Nutrients’ 2013, Castiglioni et al conducted a study titled ‘Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions’
The study discussed how magnesium homeostasis seems to be crucial for bone health. Researching previous studies Castiglioni found that both low and high magnesium levels in the body have harmful effects on the bones. Researchers conclude low levels of magnesium contributes towards osteoporosis directly (by acting on crystal formation and on bone cells) and indirectly (by impacting on function of the ‘parathyroid’ hormone and by promoting low grade inflammation).
They concluded that controlling and maintaining magnesium homeostasis is one way to help maintain bone integrity.
Gunasekara et al conducted a study titled ‘Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes’ published in DovePress 2011. Their aim was to evaluate the effects of zinc with or without other antioxidants on blood glucose, lipid profile, and serum creatinine in adult diabetics on long-term follow-up. This study demonstrates why zinc is included within the Livefit Mineral Multi formulation – zinc and multiminerals go hand in hand.
96 patients were randomly assigned to three groups: group A was supplemented with oral zinc sulfate and multivitamin/mineral (zinc+MVM); group B was given the same preparation just the multivitamin/mineral (MVM) and group C was given a matching placebo for a period of 4 months in a single-blinded study.
Results showed the zinc+MVM group had a significant change of fasting blood sugar when compared with the other two groups. The HbA1C% (glycated haemoglobin) level reduced significantly, irrespective of the baseline level, in those receiving zinc+MVM. Serum lipid levels also reduced significantly in the zinc+MVM and MVM groups.
Researchers concluded Zinc+MVM supplementation showed beneficial effects in the metabolic control of adult diabetics in addition to elevating their serum zinc level. Zinc supplementation improved glycemic control measured by HbA1C% and fasting and postprandial glucose.